129 research outputs found
Estuarine Clam Resources of Dakshina Kannada District
The estuarine clam resources of Netravathi-Gurupur, Mulki, Udayavara and Coondapur
estuaries were estimated based on a study on the distributin of clams in space and time. T he
three commercially important species were Meretrix meretrix, M. casta, and Katelysia opima
Paget-Schroetter Syndrome: Review of Pathogenesis and Treatment of Effort Thrombosis
Effort thrombosis, or Paget-Schroetter Syndrome, refers to axillary-subclavian vein thrombosis associated with strenuous and repetitive activity of the upper extremities. Anatomical abnormalities at the thoracic outlet and repetitive trauma to the endothelium of the subclavian vein are key factors in its initiation and progression. The role of hereditary and acquired thrombophilias is unclear. The pathogenesis of effort thrombosis is thus distinct from other venous thromboembolic disorders. Doppler ultrasonography is the preferred initial test, while contrast venography remains the gold standard for diagnosis. Computed tomographic venography and magnetic resonance venography are comparable to conventional venography and are being increasingly used. Conservative management with anticoagulation alone is inadequate and leads to significant residual disability. An aggressive multimodal treatment strategy consisting of catheter-directed thrombolysis, with or without early thoracic outlet decompression, is essential for optimizing outcomes. Despite excellent insights into its pathogenesis and advances in treatment, a significant number of patients with effort thrombosis continue to be treated suboptimally. Hence, there is an urgent need for increasing physician awareness about risk factors, etiology and the management of this unique and relatively infrequent disorder
Fast path and polarisation manipulation of telecom wavelength single photons in lithium niobate waveguide devices
We demonstrate fast polarisation and path control of photons at 1550 nm in
lithium niobate waveguide devices using the electro-optic effect. We show
heralded single photon state engineering, quantum interference, fast state
preparation of two entangled photons and feedback control of quantum
interference. These results point the way to a single platform that will enable
the integration of nonlinear single photon sources and fast reconfigurable
circuits for future photonic quantum information science and technology.Comment: 6 page
Nano-optical photoresponse mapping of superconducting nanowires with enhanced near infrared absorption
Superconducting nanowire single-photon detectors (SNSPDs) play an important role in emerging optical quantum technologies. We report on advanced nanometric characterization of a high efficiency near infrared SNSPD design based on a low roughness Tantalum pentoxide (Ta2O5)/ silicon dioxide (SiO2) distributed Bragg reflector (DBR) cavity structure. We have performed high resolution transmission electron microscopy (TEM) analysis to verify the smoothness of the DBR. Optical reflectance measurements show excellent correspondence with DBR simulations. We have carried out precision nano-optical photoresponse mapping studies at 940 nm wavelength at T = 3.5 K, indicating excellent large area device uniformity (peak efficiency 55 % at 100 Hz dark count rate [DCR]) with a full width half maximum (FWHM) timing jitter of 60 ps. With manual fibre coupling with single mode fibre, we achieve a system detection efficiency (SDE) of 57.5% at 940 nm wavelength (100 Hz DCR) at T = 2.3 K and a low polarization dependence of 1.20 ± 0.03. For coupling with multimode fibre, we achieve SDE of 90% at 940 nm (200 Hz DCR) at T= 2.3 K. These SNSPD devices are promising candidates for use in quantum dot photoluminescence studies and optical quantum technology applications
Gallium Arsenide (GaAs) Quantum Photonic Waveguide Circuits
Integrated quantum photonics is a promising approach for future practical and
large-scale quantum information processing technologies, with the prospect of
on-chip generation, manipulation and measurement of complex quantum states of
light. The gallium arsenide (GaAs) material system is a promising technology
platform, and has already successfully demonstrated key components including
waveguide integrated single-photon sources and integrated single-photon
detectors. However, quantum circuits capable of manipulating quantum states of
light have so far not been investigated in this material system. Here, we
report GaAs photonic circuits for the manipulation of single-photon and
two-photon states. Two-photon quantum interference with a visibility of 94.9
+/- 1.3% was observed in GaAs directional couplers. Classical and quantum
interference fringes with visibilities of 98.6 +/- 1.3% and 84.4 +/- 1.5%
respectively were demonstrated in Mach-Zehnder interferometers exploiting the
electro-optic Pockels effect. This work paves the way for a fully integrated
quantum technology platform based on the GaAs material system.Comment: 10 pages, 4 figure
High-extinction ratio integrated photonic filters for silicon quantum photonics
We present the generation of quantum-correlated photon
pairs and subsequent pump rejection across two
silicon-on-insulator photonic integrated circuits. Incoherently
cascaded lattice filters are used to provide over
100 dB pass-band to stop-band contrast with no additional
external filtering. Photon pairs generated in a
microring resonator are successfully separated from the
input pump, confirmed by a temporal correlations measurements
Photon Pair Generation in Silicon Micro-Ring Resonator with Reverse Bias Enhancement
Photon sources are fundamental components for any quantum photonic
technology. The ability to generate high count-rate and low-noise correlated
photon pairs via spontaneous parametric down-conversion using bulk crystals has
been the cornerstone of modern quantum optics. However, future practical
quantum technologies will require a scalable integration approach, and
waveguide-based photon sources with high-count rate and low-noise
characteristics will be an essential part of chip-based quantum technologies.
Here, we demonstrate photon pair generation through spontaneous four-wave
mixing in a silicon micro-ring resonator, reporting a maximum
coincidence-to-accidental (CAR) ratio of 602 (+-) 37, and a maximum photon pair
generation rate of 123 MHz (+-) 11 KHz. To overcome free-carrier related
performance degradations we have investigated reverse biased p-i-n structures,
demonstrating an improvement in the pair generation rate by a factor of up to
2, with negligible impact on CAR.Comment: 5 pages, 3 figure
Analysis of detector performance in a gigahertz clock rate quantum key distribution system
We present a detailed analysis of a gigahertz clock rate environmentally robust phase-encoded quantum key distribution (QKD) system utilizing several different single-photon detectors, including the first implementation of an experimental resonant cavity thin-junction silicon single-photon avalanche diode. The system operates at a wavelength of 850 nm using standard telecommunications optical fibre. A general-purpose theoretical model for the performance of QKD systems is presented with reference to these experimental results before predictions are made about realistic detector developments in this system. We discuss, with reference to the theoretical model, how detector operating parameters can be further optimized to maximize key exchange rates
SC3: consensus clustering of single-cell RNA-seq data
Single-cell RNA-seq enables the quantitative characterization of cell types based on global transcriptome profiles. We present single-cell consensus clustering (SC3), a user-friendly tool for unsupervised clustering, which achieves high accuracy and robustness by combining multiple clustering solutions through a consensus approach (http://bioconductor.org/packages/SC3). We demonstrate that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients.V.Y.K., T.A., A.Y. and M.H. are supported by Wellcome Trust Grants. K.N.N. is supported by the Wellcome Trust Strategic Award 'Single cell genomics of mouse gastrulation'. M.T.S. acknowledges support from FRS-FNRS; the Belgian Network DYSCO (Dynamical Systems, Control and Optimisation), funded by the Interuniversity Attraction Poles Programme initiated by the Belgian State Science Policy Office; and the ARC (Action de Recherche Concerte) on Mining and Optimization of Big Data Models, funded by the Wallonia-Brussels Federation. M.B. acknowledges support from EPSRC (grant EP/N014529/1). T.C. was funded through a core funded fellowship by the Sanger Institute and a Chancellor′s fellowship from the University of Edinburgh. K.K. and A.R.G. are supported by Bloodwise (grant ref. 13003), the Wellcome Trust (grant ref. 104710/Z/14/Z), the Medical Research Council, the Kay Kendall Leukaemia Fund, the Cambridge NIHR Biomedical Research Center, the Cambridge Experimental Cancer Medicine Centre, the Leukemia and Lymphoma Society of America (grant ref. 07037) and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. W.R. was supported by BBSRC (grant ref. BB/K010867/1), the Wellcome Trust (grant ref. 095645/Z/11/Z), EU BLUEPRINT and EpiGeneSys
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